I.Blockchain—ANewModelforHealthInformationExchangesAblockchainpoweredhealthinformationexchangecouldunlockthetruevalueofinteroperability.Blockchain-basedsystemshavethepotentialtoreduceoreliminatethefrictionandcostsofcurrentintermediaries.ParticularlycompellingusecasesforblockchaintechnologyincludethePrecisionMedicineInitiative,PatientCareandOutcomesResearch(PCOR),andtheNationwideInteroperabilityRoadmap.Fortheseandotherhigh-potentialareas,determiningtheviabilityofthebusinesscaseforblockchainisparamounttorealizethebenefitsofimproveddataintegrity,decentralizationanddisintermediationoftrust,andreducedtransactioncosts.TheexchangeofPersonalHealthRecordsandHealthInformationExchange(HIE)dataviatheIntegratingtheHealthcareEnterprise(IHE)protocolisanimportantpartofaddressingthechallengesofsysteminteroperabilityandaccessibilityofmedicalrecords.Th