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基于大分子的药物控释肿瘤靶向PolymericTumor-TargetingDrugControlledReleaseDrugLoad装载定位TargetingDrugRelease释放胶束Micelles树枝状聚合物DendrimersLiposomes微脂囊聚合物-药物偶联物Polymer-drugconjugatesDrugLoad装载定位主动active被动passiveTargeting配合基-受体Ligand-receptorEPR效应EPREffect叶酸cRGD正常组织癌变部位DrugRelease释放pH温度降解磁场UV电场内因外因PDEAEMAPNIPAM-s-s-hydrazonebonds多层分子设计MolecularDesign嵌段分子量端基ATRPRAFT点击化学超分子星形开环Tumor-TargetingPeptideConjugatedpH-ResponsiveMicellesasaPotentialDrugCarrierforCancerTherapyXiangLanWu,JongHoKimTumor-Targeting,pH-Responsive,andStableUnimolecularMicellesasDrugNanocarriersforTargetedCancerTherapyXiaoqiangYang,JamisonJ.Grailer,SrikanthPillaPEG-SS-PPS:Reduct